ABSTRACT
Hypothyroidism and hyperthyroidism were induced in adult female Sprague Dawley rats by feeding 0.05% propylthiouracil and 0.0012% L-thyroxine in drinking water. Contents of protein-bound hexose, fucose, hexosamine and sialic acid in serum were estimated in experimental rats. The results showed an increase in the protein bound hexose, fucose, hexosamine and sialic acid levels in hypothyroid rats and decrease in hyperthyroid rats. The increased content of serum glycoproteins in hypothyroid rats might possibly have come from disruptions of membranes. Depleted glycoproteins in hyperthyroid animals might be due to increase in depolymerisations of glycoproteins and accelerated secretion of glycoproteins with urine.
Subject(s)
Animals , Female , Glycoproteins/blood , Hyperthyroidism/blood , Hypothyroidism/blood , Iodine Radioisotopes , Rats , Rats, Sprague-DawleyABSTRACT
Female Sprague Dawley rats were fed 5 mg linamarin daily for 10 days. Reduced glutathione (GSH) levels in blood and liver of experimental rats were analysed. The results showed an increase of 45% and 33% glutathione levels in blood and liver respectively in experimental rats. This alteration in glutathione levels could be most likely either due to increased hepatic biosynthesis or as a consequence of decreased peripheral utilization which might be appreciated due to hypothyroidal status induced by linamarin feeding.
Subject(s)
Animals , Female , Glutathione/blood , Hypothyroidism/etiology , Liver/drug effects , Manihot/toxicity , Nitriles/toxicity , Rats , Rats, Sprague-DawleyABSTRACT
Adult male rats were subjected to whole body irradiation of 400 and 1000 rads and sodium homeostasis in blood was studied on the 1st, 4th and 7th days after exposure. A significant decrease in red cell adenosine triphosphatase, progressive loss of erythrocytic potassium and alteration in influx and efflux of sodium 22 in red cells in vitro were observed in these rats.
ABSTRACT
Adult rats were subjected to the combined stress of low atmospheric pressure and temperature at a simulated altitude of 7620 metres and at 5°C for 5 hours. A significant increase in the influx of rubidium-86 and the efflux of sodium-22 was observed in erythrocytes of experimental rats in vitro. Blood 2,3-diphosphoglycerate was appreciably enhanced while blood sodium and reduced glutathione contents in the experimental animals remained unchanged.